For the past decades nanocarriers show Drug delivery systems are the innovative methods of drug administration that target particular situses inside the organism, in order to lower overall toxicity and boost bioavailability. Each medication delivery method has special features including morphological, chemical, and physical variances. This review describes the various types of nanocarriers like liposome, ethosome and transferosome with different fabrication method thin Film Hydration Technique/Rotary EvaporationSonication method, Vortexing-Sonication Method, Modified Handshaking Process, Centrifugation Process, Reverse-Phase Evaporation Method, Ethanol Injection Method etc. With this respect therapeutic effect and pharmacokinetic effect of nanocarriers describe briefly with their evaluation parameter Vesicle Morphology, Vesicle size and size distribution, entrapment efficiency, Zeta potential, Measurement of surface tension, Physical stability, In-vitro drug release, In-vitro skin permeation studies etc.