Since the excellent physicochemical and biocompatible properties, NLCs have created an urgent need for the development of safe and valuable drug delivery methods. NLC-based formulations have been published and patented in recent years. They are a binary system that incorporates both solid and liquid lipids with the goal of producing a lipidic core that is less organised. Their ingredients have a significant impact on the finished product's physicochemical qualities and effectiveness. Accomplished applications of NLCs is emphasized in this review article. More NLCs must be used in order to overcome the constraints posed by the technological process of lipid-based nanocarrier creation and to gain a better understanding of the key mechanisms of their transport via diverse routes of administration. They can be administered by a variety of methods, including oral, cutaneous, ophthalmic, and pulmonary. This review paper aims to provide an overview of the current state of the art in the field of NLCs for future clinics by demonstrating how they can be used effectively. The data clearly shows that NLCs have the potential to be used in novel therapeutic applications in the future