According to the World Health Organization (WHO), Zoonotic diseases are those that are naturally transferred between vertebrate animals and humans as well as infections that are shared between vertebrates and humans. The zoonotic diseases include viral (rabies, yellow fever, influenza, Kyasanur forest disease, etc.), bacterial (anthrax, brucellosis, plague, leptospirosis, salmonellosis, etc.), rickettsial (tick typhus, scrub typhus, murine typhus, etc.), protozoal (toxoplasmosis, leishmaniasis, trypanosomiasis (scabies, myasis, etc.). The WHO classifies South East Asian zoonotic diseases into three categories: endemic, re-emerging, and emerging diseases with epidemic potential. 816 of the 1407 human diseases are zoonotic, or able to spread naturally from animals to people. These include protozoa, 208 viruses, 287 helminths, 317 fungi, 538 bacteria and rickettsia. In this article, we focus on the recent updates of the Zoonotic diseases in the Indian subcontinent, their epidemiology, impact, control and treatment. The public health stakeholders in India as well as in Southeast Asia should emphasize on understanding the eco-epidemiology of the discussed zoonotic