Diabetes and depression continue to be major public health burdens throughout the globe. Several studies suggest a reciprocal relationship between depression and diabetes (2): Depression occurrence is twice to thrice higher in people with diabetes mellitus when compared to non-diabetic people and they majorly remain undiagnosed (6). In contrast, depression increases the risk of diabetes and interferes with its daily self-management (2). The purpose of this review was to show the links between depression and diabetes, point out the significance of identifying depression in diabetic patients and identify the possible ways to address both diseases (6). A focused discussion of the proposed mechanisms underlying this reciprocal relationship is also provided (2). An important aspect is to understand the common origins of diabetes and depression and to get aware of this quite common comorbidity, in order to improve the outcomes of management of both diseases (6). Therefore, this review aims to highlight the most notable body of literature that dissects the various facets of the reciprocal relationship between diabetes and depression (2).