Lead as one of the environmental pollutants can threats the life of living creatures in many ways. It is a poisonous metal and ecological pollutant famous to health of human and animal from long time .The goal of this ready labor was to Clarify type of anemia by influence on complete blood picture , some biochemical tests , PPOX enzyme and clinical signs that induced experimentally by lead.A sixteen local rabbits were divided into two groups, each group have 8 rabbits, control negative were taken food and water only and positive group given lead acetate at 10 mg/ kg/day for 30days.Gathering blood samples to analyze hematological and biochemical tests . After 4 weeks of exposure lead acetate the results showed a significant reduction in Hb ,pcv, MCV, MCH, MCHC ,body weight ,ppox and RBCs counts .From another side a significant increase in RDW and bilirubin concentration were looked . From this study that the decreased in red blood cells indices and hemoglobin concentration led to anemia in animal groups that had administered lead acetate 10mg/kg/Bw