Mucormycosis is an aggressive fungal disease caused by a saprophytic fungus can occur in individuals with certain predisposing factors, such as diabetes mellitus and pharmacologic immunosuppression. An astounding aspect of this disease is the speed at which it can spread to surrounding structures once it begins to germinate inside the human body. Oral cavity is one such area which can easily harbour fungi, bacteria and viruses due to rich blood supply and being an opportunistic infection, Mucormycosis that can easily involve maxilla, nasal cavity as well as paranasal sinuses leading to necrosis of the underlying bone and soft tissues leaving the affected individual with a large maxillary defect requiring dento-facial rehabilitation. In such patients, comprehensive knowledge, understanding, and skills in the treatment are required for prosthetic facial rehabilitation. This case report describes the management of maxillary defects with a custom-made speech aid prosthesis. To rehabilitate the patients with an overall goal to regain confidence and improve the patient’s quality of life.