Social isolation and depression in older adults are major public health problems and associated with increased morbidity and mortality, and negatively impact their nutritional status including malnutrition. Therefore, this study aimed to assess the relation of social isolation and depression on nutritional status of elderly at Abu Hammad City, Sharkia Governorate. Design: A descriptive design was used. Setting: This study was conducted at a village called " Bahtet" at Abu Hammad City, Sharkia Governorate. Sample: A purposive sample consisted of 125 elderly. Tools: Four tools were used for data collection: Tool I: A structured interview questionnaire composed of two parts; demographic characteristics, and medical history of the studied sample, Tool II: The Mini Nutritional Assessment. Tool III: Lubben Social Network Scale-Revised, and Tool IV: The Geriatric Depression Scale: short form. Results: 60.8% of the elderly were at risk of malnutrition. Also, 20.8% of them had normal nutritional status, while 18.4% of them were malnourished. 53.6% of the elderly had moderate level of social network, and 17.6% had high level. Moreover, 28.8% of them had low level. 48% of the elderly had mild depression, additionally 4.4% & 5.6% of them had moderate and severe depression respectively. The study indicated that there was a highly significant relation between nutritional status of the elderly and depression and social network (P= < 0.01). Conclusion: less than two thirds of the elderly were at risk of malnutrition, and the minority of them were malnourished. Additionally, more than half of the elderly had moderate level of social network. Moreover, slightly less than half of the elderly had mild depression. The study indicated that there was significant relation between nutritional status of the elderly and depression, Social network. Recommendation: Replicate the study on a larger group; selected from different geographical areas in Egypt to obtain more generalized findings in relation to current study.