Bipolar disorder, formerly known as Manic depression is a mental illness marked by emotional highs (mania or hypomania) and lows (depression), which affects more than 1% of the world's population.Depression is common and harmful in children and adolescents, and it often heralds a chronic and repeated course of illness.Mixed mania was reported frequently in teenagers and individuals with a history of mania, particularly in females.In women, increasedYoung Mania Rating Scale(YMRS) core ratings resulted in a linear rise in depression load, and females were considerably more likely than males to suffer a greater number of depressive symptoms. Approximately half of the hypomanic and manic patients were also likely to meet the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) mixed feature specifies, with a considerable female predominance.In individuals with Bipolar II disorder (BD-II), as well as those who have a high number of mixed manic-depressive episodes and those who follow a Myotonic dystrophy type 1 (DM1) course pattern, there is a significant excess of depression.