The challenges of wastewater treatment lie in implementing cost-effective, high performance, ecovative, and straightforward techniques. One of the efficient and economical methods is treating the water by suitable adsorbents. Adsorption is a simple physicochemical process that transfers the pollutant from liquid to solid phase. Though adsorbents like activated carbon, silica, and alumina are commercially available; bio adsorbents gain attention and importance because of their low cost, adsorption capacity, and eco-friendly enabled solutions. Although many bioadsorbents have emerged with significant results in the present review, we extended our vision on the competency of neem (Azadirachta indica) leaves in the removal of heavy metal ions and organic dyes since it is well known for its therapeutic use. The study assesses that the adsorption process's effectiveness and challenges depend on the adsorbate's affinity and the adsorbent. The factors like the dosage of adsorbent, the concentration of adsorbate, the contact time between them, agitation, and pH of the medium also quantify adsorption's viability