Among the most prevalent side effects of radiotherapy for the head and neck (HN) tumors is radiation dermatitis. Purpose of the Study: This study was conducted to investigate the impact of photon therapy in reducing dermatitis during radiotherapy in patients with HN tumors. Methods: A randomized controlled trial (RCT), 60 HNC patients were included and were given radiotherapy (RT) with or without chemotherapy. They were randomized into two groups of equal number, control group (CG) as well as study group (SG). Throughout radiotherapy, both groups received standard nursing care, which consisted of health education, skin self-care, as well as a skin protective agent. The patients in the study group were treated with photon therapy (3x/week) for 6 weeks with a total of 18 sessions. The severity of skin reactions was assessed by the criteria of the Radiation Therapy Oncology Group (RTOG) and dermoscopy for both groups were recorded. Results: The incidence of (RTOG scale) was significantly higher in the control group (CG) than in the photon therapy (SG) group. The dermoscopy score (including erythema, scaling, and pigmentation) also showed a significant reduction in photon therapy group (SG) than control group (CG). Conclusion: This randomized controlled trial demonstrated that photon therapy could be efficient in decreasing the incidence of acute radiation dermatitis in HNC patients undergoing radiation therapy based on RTOG scale and dermoscopy measurements.