Introduction: Hip arthrosis is a serious, relentlessly progressive and disabling complication in sickle cell positive patients; majority of patients are in their second to third decades of life and usually present to the Orthopedic surgeon at a late stage often after being debilitated. Early stages of osteonecrosis of femur head can be treated pharmacologically or by core decompression. Since there is late presentation by the patient, only available option for providing a good quality of life with painless mobile joint is total hip arthroplasty. In this study, we have assessed the outcome following total hip arthroplasty in the form of pain reduction, ability to perform routine activities, return to occupation, implants used, methods to reduce complications etc. Patients had improved Harris hip score following surgery with less complications which is encouraging to conduct total hip arthroplasty in sickle cell positive patients.