Cancer is the leading cause of death worldwide and is still increasing nowadays. Several natural products and their derivatives have been of interest for their anti-cancer activities and have been intensively studied for their applications. In this study, we focused on developing a curcumin analog ([(1E, 6E) -1, 7-bis (3, 4-dimethoxyphenyl) hepta-1, 6-diene-3, 5-dione or dimethylcurcumin (DMC)], resveratrol (RES), and co-loading of both compounds in nanomicelles to improve the loading capacity and water solubility. Pluronic F-127 was utilized as a nanomicelles construction by thin film hydration method. Preparations of DMC, Res, and co-loaded DMC and Res nanomicelles were optimized by varying the ratios between the loaded drug(s) and Pluronic F-127. The stable nanomicelles gave clear solutions, and the obtained freeze-dried powders could re-disperse in water. Their sizes were in a range of 20- 50 nm, in spherical form with zeta potentials in a range of -9 – -12 mv. All formulations with 200 mg of pluronic-F-127 in a final solution of 4 ml could encapsulate Res and DMC up to 23.17 ± 0.88 mg and 1.50 ± 0.03 mg, respectively. However, when DMC was co-loaded with 20 mg of Res, a clear solution with a much higher loading capacity of 3.74 ± 0.07 mg (about 2.5 times) was observed which may be induced, by - interaction and H-bonding. The FT-IR, DSC, and p-XRD results demonstrated that DMC and Res were dispersed in dried powder in amorphous forms. The obtained nanomicelles are useful for further investigation for anti-breast cancer treatment.