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BIOCHEMISTRY OF FASTING – A REVIEW ON METABOLIC SWITCH AND AUTOPHAGY.
Volume - 13 | Issue-1
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ONE-POT ENVIRONMENT FRIENDLY SYNTHESIS OF IMINE DERIVATIVE OF FURFURAL AND ASSESSMENT OF ITS ANTIOXIDANT AND ANTIBACTERIAL POTENTIAL
Volume - 13 | Issue-1
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MODELING AND ANALYSIS OF MEDIA INFLUENCE OF INFORMATION DIFFUSION ON THE SPREAD OF CORONA VIRUS PANDEMIC DISEASE (COVID-19)
Volume - 13 | Issue-1
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INCIDENCE OF HISTOPATHOLOGICAL FINDINGS IN APPENDECTOMY SPECIMENS IN A TERTIARY CARE HOSPITAL IN TWO-YEAR TIME
Volume - 13 | Issue-1
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SEVERITY OF URINARY TRACT INFECTION SYMPTOMS AND THE ANTIBIOTIC RESISTANCE IN A TERTIARY CARE CENTRE IN PAKISTAN
Volume - 13 | Issue-1
RESVERATROL SLOWS DOWN EPITHELIALMESENCHYMAL TRANSITION IN HEPATOCELLULAR CARCINOMA VIA MODULATION OF AKT/GSK3Β/SNAIL1 SIGNALING PATHWAY
Main Article Content
Abstract
Background: Epithelial-mesenchymal transition (EMT) is one of the main targets for controlling hepatocellular carcinoma (HCC). In this study, resveratrol (RES) was evaluated for its anti-cancer activity in vivo via modulation of EMT in HCC, and for its pro-apoptotic activity in HepG2 cell line in vitro. Methods: Rats were divided into five groups. Group-1 received the vehicles; Group-2 received RES; Group-3 received diethylnitrosamine (DEN) and carbon tetrachloride (CCl4); Group-4 received RES pretreatment and DEN/CCl4; Group-5 received DEN/CCl4 and RES posttreatment. Oxidative stress and hepatic function were evaluated. Akt and glycogen synthesis kinase3β (GSK3β) expression levels were determined. Furthermore, the impact of RES on HepG2 cell viability was investigated.
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