Butylated hydroxytoluene (BHT), a classical antioxidant used in pharmaceutical, polymer and food industry. BHT possess several pharmacological activities such as antioxidant, anti-inflammatory, antiulcer and antitumor activities. The sterically hindered phenol moiety appears to be attracting structural feature of BHT. Several compounds having BHT moiety were developed and screened for the possible biochemical and pharmacological activities