Pseudomonas aeruginosa is versatile and can be found in warm moist environments like sinks, drains, respirators, humidifiers, and disinfectant solutions available in most hospitals. The human fecal carriage of this organism is around 3% which may increase with the duration of hospital stay because of the selective pressure of antibiotics (1) A wide spectrum of infections are caused by Pseudomonas aeruginosa that are difficult to treat given its ability to acquire resistance to all classes of antimicrobial agents (2). Several mechanisms exist synchronously to bestow resistance to strains of pseudomonas aeruginosa, increasing mortality higher (3) This study was conducted in a tertiary hospital near Chengalpet, Tamilnadu among the in-patients to find prevalence, risk factors, and susceptibility pattern, corresponding to Multidrug-resistant Pseudomonas aeruginosa (MDRPA)