Background: A common manifestation of lung cancer is central involvement of the airway. Bronchoscopic electrocautery, laser, argon plasma coagulation (APC), cryotherapy, photodynamic therapy, brachytherapy, intra-tumoral chemotherapy, mechanical debridement, and rotational micro-debrider are common treatments for patients with endobronchial neoplasms with the goals of debulking and palliation. Cryotherapy causes local tissue destruction by the application of extremely low temperatures (below -15 to -40°C). The profound cooling that occurs at the tip from the rapid expansion of gas results in intracellular and extracellular cryogenesis with coagulation necrosis