Background: Chronic diseases are a growing concern worldwide, particularly among the elderly population, leading to significant healthcare costs and medical consultations. Strategies such as self-management and promoting healthy behaviors, including physical activity, are crucial in addressing these health challenges. However, there are barriers to implementing exercise interventions in clinical practice, including a lack of awareness, inadequate descriptions of interventions in published studies, and limited training opportunities for medical practitioners. Aim: This study aims to investigate the effectiveness of exercise interventions in managing chronic conditions such as arthritis, diabetes, and heart disease. It seeks to evaluate the impact of exercise on improving functional abilities, quality of life, reducing pain and inflammation, and assessing the socio-economic impact of chronic diseases. Additionally, the study aims to identify barriers and facilitators to incorporating exercise into physiotherapy treatment plans for chronic condition. So, we concluded that regular physical activity and exercise play a crucial role in preventing and managing chronic diseases such as diabetes and osteoarthritis. Exercise interventions have shown positive effects on glucose metabolism, insulin sensitivity, muscle strength, and pain management in individuals with chronic conditions. However, challenges exist in prescribing and implementing exercise regimens in clinical settings. Addressing these challenges and promoting physical activity as a form of medicine can lead to improved health outcomes, reduced healthcare costs, and enhanced quality of life for individuals with chronic diseases. Further research and efforts are needed to overcome barriers and integrate physical activity promotion effectively into the treatment of chronic conditions.