This study is an attempt to assess the dynamic role of industrialization and urbanization in providing references for regional sustainable development in the specific context of selected Tier-II cities of India, namely – Bikaner, Jodhpur, Jaipur, and Kota. Based on the review of extant literature and secondary data compiled from various sources, the study observes that industrialization is one of the main catalysts of the urbanization of Tier-II cities. With the establishment and expansion of industries, the Tier-II cities have experienced population growth, physical & demographic expansion, increased manufacturing and commercial activities, better employment opportunities, and infrastructure development. Industrialization and urbanization are quite determinants of sustainability, apart from the economic growth and opportunities for individuals and businesses. The study concludes that with developed infrastructure and connectivity, low pollution levels, fewer traffic bottlenecks, and rising industrial & employment opportunities, Tier-II cities have the potentiality to attract new capital investment. Hence, policymakers should think hard and act seriously to minimize the consequences of industrialization and urbanization so that they are useful for the sustainable development of not only Tier-II cities but all urban centers across the country