Maxillofacial prosthodontics involves rehabilitation of patients with defects or deficits of face, jaws and surrounding soft tissues that may have occurred through developmental defects, traumatic injury or any disease. Radiation can damage areas in the head and neck region that are not necessarily affected by cancer. Prosthetic devices can be fabricated to anchor or protect facial structures from radiation exposure. Positioning devices fabricated by Prosthodontists protect these areas during treatment. Maxillofacial Prosthodontists play an essential role in palliative care team as well, he/she is the primary person involved in many facets of patient care, and is therefore the individual who is in the best position to coordinate in smooth functioning required in this complex rehabilitative process which can be enhanced using various surgical stents and splints. All these prosthetic appliances can fulfil the needs of such patients and prevent the development of further complications thus alleviating their discomfort and help them to live a better life.