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BIOCHEMISTRY OF FASTING – A REVIEW ON METABOLIC SWITCH AND AUTOPHAGY.
Volume - 13 | Issue-1
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ONE-POT ENVIRONMENT FRIENDLY SYNTHESIS OF IMINE DERIVATIVE OF FURFURAL AND ASSESSMENT OF ITS ANTIOXIDANT AND ANTIBACTERIAL POTENTIAL
Volume - 13 | Issue-1
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MODELING AND ANALYSIS OF MEDIA INFLUENCE OF INFORMATION DIFFUSION ON THE SPREAD OF CORONA VIRUS PANDEMIC DISEASE (COVID-19)
Volume - 13 | Issue-1
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INCIDENCE OF HISTOPATHOLOGICAL FINDINGS IN APPENDECTOMY SPECIMENS IN A TERTIARY CARE HOSPITAL IN TWO-YEAR TIME
Volume - 13 | Issue-1
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SEVERITY OF URINARY TRACT INFECTION SYMPTOMS AND THE ANTIBIOTIC RESISTANCE IN A TERTIARY CARE CENTRE IN PAKISTAN
Volume - 13 | Issue-1
Role of NGS based genomic profiling analysis in identifying targetable genetic alterations in pediatric western Saudi Arabia sarcomas patients: Advanced insights into PTEN
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Abstract
Background: PTEN is one of the frequently mutated genes in different sarcoma subtypes. This study aims to investigate the potential role and alterations of the PTEN gene in various pediatric sarcoma cases. Methods:169 Saudi pediatric sarcomas patients had full clinical and follow-up data. Next generation sequencing (NGS)-based genomic profiling analysis was done for pediatric sarcomas cases, including rhabdomyosarcoma (RMS), osteosarcoma (OS), and Ewing's sarcoma (ES). Detection of PTEN gene mutation and its asocaiation with loss of PTEN protein expression was investigated. Results: PTEN protein expression was lost in 54 (31.9%) of studied cases. For different sarcoma subgroups,
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