Radiopharmaceuticals are essential in the diagnosis and treatment of various medical conditions, including cancer, cardiovascular diseases, and musculoskeletal disorders. Nurses play a vital role in the safe and effective administration of these medications, ensuring patient safety and treatment efficacy. This article discusses the responsibilities of nurses in preparing, administering, and monitoring radiopharmaceuticals, highlighting the importance of proper training and adherence to protocols. Additionally, the article examines the challenges and considerations associated with the administration of radiopharmaceuticals, such as radiation safety precautions, patient education, and interdisciplinary collaboration. By understanding the critical role of nurses in this aspect of healthcare, healthcare professionals can optimize patient care and outcomes in physiotherapy settings. This review article explores the crucial role of nurses in the administration of radiopharmaceuticals for the treatment of specific physiotherapy conditions.