Sepsis remains a critical medical condition with substantial morbidity and mortality rates globally. This narrative review article explores the pivotal role of nurses in sepsis recognition and early management, highlighting their contributions across various domains of care. The review underscores the significance of nurses in sepsis care, emphasizing their unique position as frontline healthcare providers with critical assessment skills and clinical expertise. Clinical presentation is discussed through the lens of systemic inflammatory response syndrome (SIRS) criteria, Sequential Organ Failure Assessment (SOFA) score, and Quick Sepsis-related Organ Failure Assessment (qSOFA) score, highlighting the tools nurses employ for risk assessment and prognostication. The role of nurses in sepsis recognition is examined, encompassing early warning signs, assessment tools, and communication strategies essential for timely intervention. Nursing assessment and interventions delve into initial assessments, hemodynamic monitoring, and laboratory diagnostics crucial for tailored patient care. A collaborative care approach is emphasized, emphasizing interdisciplinary communication, nursing leadership, and patient/family education. Nursing interventions in early sepsis management, including fluid resuscitation, vasopressor therapy, and antibiotic administration, are explored in detail. Additionally, the review covers nursing management of complications such as acute respiratory distress syndrome (ARDS), septic shock, and Disseminated Intravascular Coagulation (DIC), as well as nursing care during the sepsis recovery phase. The review concludes with a recap of key findings, implications for nursing practice, and recommendations for further research, emphasizing the critical role of nurses in optimizing sepsis outcomes and advancing patient care.