Introduction: Age-related macular degeneration (AMD) is a medical condition which may result in blurred or no vision in the center of the visual field. Early on there are often no symptoms. Spectral domain optical coherence tomography (SD-OCT) is a noninvasive imaging technique, able to visualize structural changes of the neuro sensory retina and the retinal pigment epithelium (RPE). Intravitreal injection is the standard method of administration, of antivascular endothelial growth factor Anti-VEGF which block its interaction with receptors on the endothelial cell surface and so retard or reverse vessel growth