Introduction: - Subclinical hypothyroidisms are common clinical entities that encompass mild degrees of thyroid dysfunction. It is an early, mild form of hypothyroidism, where serum level of thyroid-stimulating hormone from the front of the pituitary gland is a little bit above normal. oxidative stress markers can be helpful in assessment of adverse effects of subclinical hypothyroidism, are not very well studied in the past. So, the aim of this study was to investigate the role of oxidative stress markers on subclinical hypothyroidism and its association with hs-CRP in Subclinical hypothyroidism patients Materials and Methods: The study population consisted of 150 patients with recently diagnosed subclinical hypothyroidism and 150 healthy controls. TSH, FT4 & T3 were estimated by enzyme linked Immunosorbent assay (ELISA) for diagnosis of subclinical hypothyroidism. The SOD activity was estimated by method described by Kono, 1978 by observing the inhibitory rate of NBT (Nitroblue tetraz olium) reduction. Hs-CRP was estimated by enzyme linked Immunosorbent assay (ELISA). Results: In this study the level of TSH Mean ± SD (9.92±2.42 vs 1.95±1.01) and T3 Mean ± SD (1.01±0.32 vs 1.26±0.34) and T4 Mean ± SD (8.44±0.92 vs 7.67±1.42) were significantly higher (<0.001) in subclinical hypothyroidism. TSH, T4, level was positively correlated with Malondialdehyde and Superoxide Dismutase and hs-CRP in subclinical hypothyroidism. Conclusion: In conclusion subclinical hypothyroidism patients have raised oxidative stress markers and hs-CRP, this may be due to that future risk and further progression. Level of hs-CRP increases in patients as disease progress if left untreated.