In recent years, there has been a growing recognition of the crucial role that pharmacists play in promoting medication safety in pediatric patients. This review article aims to explore the various ways in which pharmacists contribute to ensuring the safe and effective use of medications in this vulnerable population. Pharmacists serve as key members of the healthcare team, providing expertise in medication management, drug information, and patient education. They play a pivotal role in preventing medication errors, adverse drug reactions, and drug interactions in pediatric patients through their involvement in medication reconciliation, counseling, and monitoring. Pharmacists collaborate with healthcare providers to optimize medication therapy, taking into account the unique pharmacokinetic and pharmacodynamic considerations in pediatric patients. They work closely with parents and caregivers to ensure proper administration and dosing of medications, as well as to address any concerns or questions regarding therapy. Pharmacists also contribute to the development and implementation of medication safety protocols and guidelines specific to pediatric populations, aiming to reduce the risk of medication-related harm. Furthermore, pharmacists play a critical role in promoting medication adherence among pediatric patients, helping to improve treatment outcomes and reduce the likelihood of medication errors. They utilize their knowledge and communication skills to empower patients and families to take an active role in managing their medications safely. Additionally, pharmacists engage in ongoing education and training to stay abreast of the latest advancements in pediatric pharmacotherapy and medication safety practices. Pharmacists are indispensable in promoting medication safety in pediatric patients through their expertise, collaboration with healthcare teams, and dedication to patient-centered care. This review highlights the multifaceted contributions of pharmacists in safeguarding the health and well-being of pediatric patients through optimized medication management and enhanced medication safety practices.