Pharmacogenomics plays a crucial role in personalized medication therapy for patients in nursing care by tailoring drug treatments based on an individual's genetic makeup. This review article explores the significance of pharmacogenomics in optimizing medication therapy for patients in nursing care settings. The integration of pharmacogenomic testing into clinical practice has the potential to enhance treatment outcomes, minimize adverse drug reactions, and improve patient safety. By identifying genetic variations that influence drug response, healthcare providers can make informed decisions regarding drug selection, dosing, and monitoring, leading to more effective and personalized patient care. This article discusses the current state of pharmacogenomics research, its applications in nursing care, challenges in implementation, and future directions in the field.