Periodontitis is a chronic inflammatory disease that leads to progressive destruction of the connective tissues and bone with subsequent tooth mobility and eventual exfoliation. It is known to be episodic in nature, consisting of periods of exacerbation, and remission. For a long time, bacteria and host response have been considered the determinants for periodontal disease and health. In addition to the above, the role of other microorganisms is still being debated. Thus, the etiology of the disease is now thought to be multiple infectious agents, and interconnected cellular and humoral host immune responses. However, it is difficult to unravel the precise role of various putative pathogens, and host responses in the etiopathogenesis of periodontitis. This led to speculation and research, to discover a new aspect to the pathogenesis of periodontitis. This review article aims to widen the horizon of knowledge with regard to viruses and the pivotal role they play in periodontal destruction.