An optimal preventative approach should aim to eradicate CRBSI from all sites where patients get treatment. While the task is difficult, programs have shown achievement. However, maintaining eradication necessitates ongoing dedication. The objective of this narrative review was to examine the significance and function of healthcare providers in the prevention of catheter-related bloodstream infection (CRBSI), encompassing physicians, nurses, and all other members of the healthcare team. Effective prevention necessitates the implementation of evidence-based strategies, such as employing strict sterile precautions during catheter insertion, utilizing checklists and maintenance procedures, emphasizing the importance of sterile a catheter access approach and maintaining catheter dressing integrity, and considering the use of preventive antimicrobial agents in certain circumstances.