Introduction: Powered toothbrush has been developed as an alternative to manual tooth brush. It is crucial to understand if powered toothbrushes are safer and more beneficial for oral health applications than manual toothbrushes. Objectives: Based on information that has been published in the literature, assess the efficacy and safety of powered and manual toothbrushes. Materials and methods: Trials from which pertinent data could not be collected were eliminated from the evaluation, which was conducted in accordance with “Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria”.