An important etiological factor responsible for diabetic vascular complications is endothelial dysfunction, which is characterized by an imbalance between endothelial-derived vasoconstrictor factor, Endothelin-1 (ET-1). The levels of Endothelin-1 are characteristically increased in diseased periodontal tissues. Considering these factors , the current study evaluated and compared salivary Endothelin-1 levels among healthy, periodontitis, Type II diabetic, and Type-II diabetes with periodontitis subjects.100 individuals fulfilling the inclusion and exclusion criteria were divided into 4 groups. Group 1 (Systemically healthy subjects without generalized periodontitis), Group 2 (Subjects with generalized periodontitis), Group 3 (Periodontally healthy subjects with type-2 Diabetes), and Group 4 (Subjects with Type-II diabetes with generalized periodontitis). Saliva samples were collected from all four groups. Salivary Endothelin-1 levels were determined through ELISA analysis. The data obtained was then subjected to statistical analysis. Results indicated significantly elevated Salivary Endothelin-1 levels in group 4 (diabetes along with periodontitis) when compared to the healthy group. Overall comparative analysis revealed raised salivary Endothelin -1 levels in group 2, group 3, and group 4 when compared to the healthy group (p< 0.0015**). The results of this study suggest that patients suffering from periodontitis and diabetes have higher salivary levels of Endothelin-1 than subjects with periodontitis and healthy controls indicating its fundamental role in the bidirectional relationship between diabetes and periodontitis. Therefore, Endothelin-1 can be considered a surrogate Salivary biomarker for Type-II Diabetes Mellitus and periodontitis.