The main pathogenic trait of the corona virus disease 2019 (COVID-19), which is caused by the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), is an immune response that is overly activated and results in an excessive release of pro-inflammatory mediators in the alveoli and lung structures.The cytokine hyper activation in COVID-19 appears to be comparable to that seen in the autoimmune condition mainly rheumatoid arthritis (RA). RA patients now understandto an extent the gravity and danger of COVID-19 because to new information. The findings of musculoskeletal symptoms involving immune-inflammation-dependent mechanisms and cases of arthralgia and/or myalgia in COVID-19 are commonly discussed in the context of crosstalk between COVID-19 and RA.By using multiple Serological and Molecular profiling, we attempted to identify a clinical association between RA and COVID-19. The severity of both was compared between the sexes. Additionally,the relationship was alsoestablished between COVID -19 and RA cases in rural and urban locations.