The main pathogenic trait of the corona virus disease 2019 (COVID-19), which is caused by the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), is an immune response that is overly activated and results in an excessive release of pro-inflammatory mediators in the alveoli and lung structures.The cytokine hyper activation in COVID-19 appears to be comparable to that seen in the autoimmune condition mainly rheumatoid arthritis (RA). RA patients now understand to an extent the gravity and danger of COVID-19 because to new information. The findings of musculoskeletal symptoms involving immune-inflammation-dependent mechanisms and cases of arthralgia and/or myalgia in COVID-19 are commonly discussed in the context of crosstalk between COVID-19 and RA.By using multiple Serological and Molecular profiling, we attempted to identify a clinical association between RA and COVID-19. The severity of both was compared between the sexes. Additionally,the relationship was alsoestablished between COVID -19 and RA cases in rural and urban locations. The majority of positive cases in Dehradun occurred in urban areas (n=578), followed by rural regions (n=141), and mixed areas (n=75), albeit the number of positive cases was considerably lower compared to the first and second waves. After the normality had been examined, The CT values looked to have come from a population that was regularly distributed even though they showed no specific pattern. Since random individuals were selected, the population was not under control. The P value for Highly Positive CT findings was (p = 0.03370), Mean ± SD 17.896 ± 2.081 and n=22. for Mid Positive cases,(p = 0.22830), Mean ± SD 33.280 ± 1.480 and n=35.Even in Low Positive where (p < 10- 4), Mean ± SD 27.309 ± 2.733, the distribution of CT values did not always appear to have come from a population with a normally distributed distribution. The average age of the Covid-19- positive females was 48 years, but the average age of the Covid-negative males was 42 years, showing that females with Covid infection have a higher risk of developing RA, and vice versa. Autoimmune diseases are strongly related to immune system decline, which can surely attract many pathogens. There is still much that has to be developed in order to safeguard people's health.