The study aimed to assess the Quality of Life (QoL) and Suicidal Ideation (SI) among women with Polycystic Ovary Syndrome (PCOS) compared to a control group. A total of 104 women aged 16-35 years were recruited from Outpatient Departments of various hospitals in India, using the Rotterdam criteria for PCOS. Purposive sampling technique was used for 49 PCOS sufferers, while 55 controls were selected using random sampling. The WHO Quality of Life-BREF (WHOQOL-BREF) and Suicidal Ideation Scale were used to collect data. Student t-test, Pearson product-moment correlation, and Linear Regression were used for statistical analysis. Results showed that PCOS women had significantly lower mean QoL scores in the psychological domain (18.57±4.26) compared to other domains such as environment (29.38±5.02), social relationship (10.93±1.87), and physical health (23.18±4.52). Additionally, PCOS women exhibited a significantly higher mean SI score (62.04±14.26) compared to the control group. The Linear Regression analysis revealed that Quality of Life significantly predicted Suicidal Ideation among PCOS women, indicating that QoL accounted for 25.5% of the explained variability in Suicidal Ideation. The outcomes of this study offer valuable insights, highlighting a clear connection between reduced quality of life and increased instances of suicidal thoughts in women dealing with Polycystic Ovary Syndrome (PCOS). This underscores the importance of acknowledging and tackling the psychological dimensions when managing PCOS. Interventions like primary therapies, cognitive-behavioral approaches, and involvement in PCOS support groups hold significant potential for enhancing outcomes, elevating both quality of life and the management of suicidal ideation among individuals with PCOS.