Breast cancer remains a significant global health concern, necessitating advancements in therapeutic strategies. Recent scientific investigations have focused on the potential of silver nanoparticles (AgNPs) as an innovative tool for targeted breast cancer therapy. AgNPs have demonstrated unique properties including a high surface area-to-volume ratio, tunability of size and shape, and superior biocompatibility, rendering them advantageous for drug delivery applications. Importantly, their inherent cytotoxic properties against cancer cells add an extra dimension to their therapeutic efficacy. This review article discusses the synthesis of AgNPs, their potential anticancer effects, and their ability to be utilized as targeted drug delivery systems for breast cancer treatment. It explores the mechanisms by which AgNPs exert their antitumor effects, including the induction of oxidative stress, modulation of signal transduction pathways, and interference with DNA replication. The potential of functionalizing AgNPs with various ligands for targeted delivery to breast cancer cells is also examined, with a particular emphasis on ligands targeting overexpressed receptors on breast cancer cells. The use of AgNPs for co-delivery of chemotherapeutic agents and genes is further discussed. Additionally, the review outlines the current challenges in translating AgNPs into clinical applications, including issues related to their toxicity, biodistribution, and pharmacokinetics. This comprehensive review underscores the promise of AgNPs in revolutionizing breast cancer therapy, while also emphasizing the need for more research to realize their full therapeutic potential