Human brain is one of the most complex organs in the human body. The accumulation of cerebrospinal fluid CSF in the human ventricles and subarachnoid space is called “hydrocephalus”. Fluid flow and mass transfer in human brain tissues takes place in a highly synchronised and well regulated manner. The transfer of molecules is an essential bio-process describing physiological and pathological processes associated with the brain functioning. The brain produces roughly 500ml CSF per day at the rate 25ml per hour. Due to some internal and external factors, especially by electromagnetic radiations emitted by mobile towers, resulting in some unbalanced circulation and absorption, the CSF dynamics may cause a situation known as “hydrocephalus” and is responsible in increasing the pressure in the human skull which is referred to as Intracranial Pressure (ICP). A series of mathematical models have been developed to understand the dynamics of CSF, ICP and hydrocephalus based on fluid flow and mechanics. The models are highly non-linear, time variant and complex. Moreover, the models are imprecise, uncertain, and coupled. In this paper a fuzzy logic based solution is presented to simulate the CSF dynamics using MATLAB platform.