The objective of this research is to create and assess a UV spectrometric method for concurrent measurement of Curcumin and Erlotinib in tablet form. The current approach uses the absorbance ratio of Curcumin (425 nm) and Erlotinib (335 nm) at these two wavelengths to solve a simultaneous equation. In accordance with the ICH requirements, the mathematical properties of the suggested solution were evaluated for linearity, accuracy, precision, repeatability, roughness, and robustness. Beer-Lambert law concentration ranges of 200–1000 g/ml were achieved with this method, and concentrations of 50–450 g/ml were achieved with this method for Curcumin and Erlotinib, respectively. Because of the high R2 values, the calibration plot was quite linear. Accuracy and precision of 2% were confirmed for the linked fraction of RSD and for all validation metrics