The simultaneous analysis of Lafutidine and Domperidone Maleate in tablet form has been analysed using an HPLC method that has been developed and verified. At a flow rate of 1.0 mL/min and using UV detection at 222 nm, drugs were separated chromatographically using a Hypersil BDS C8 column (250 mm x 4.6 mm, 5 ) as the stationary phase and a mobile phase of phosphate buffer (pH adjusted to 4.5 with orthophosphoric acid):methanol:acetonitrile in the ratio 55:25:20 (v/v/v). Lafutidine had a retention time of 4.07 minutes, while domperidone took 6.13 minutes. The technique was found to be selective, with clearly distinguishable peaks for Lafutidine and Domperidone (resolution = 9.82). Linearity (R2 = 0.999) and accuracy (99.45-100.08% for Lafutidine and 99.20100.12% for Domperidone) as well as precision (%RSD 2%) characterise the suggested approach. The approach has been used to measure the effectiveness of commercial products, and those results have been found to be within acceptable ranges. Analysing tablet forms of Lafutidine and Domperidone is possible using this technique