Background: Skin complications are a common occurrence in orthopedic patients, and they can significantly impact patient outcomes and quality of life. Knowledge of these complications and contributing factors is important for design and development of preventive approaches. Therefore, this study was designed to assess skin complications in orthopedic patients. Methods: In this case-series study, 53 orthopedic patients referred to Divisional Railway hospital, Ambala from 2019 to 2020 with skin complications were analyzed. The adverse effects were assessed with respect to type and contributing factors. Fisher’s exact test, Chi-square, and independent sample t-test were performed to assess the associations between skin complications and other variables. Results: In total, 30 (55.5%) cases of fracture and 5 (9.4%) cases of cellulitis were studied, while the remaining cases presented with osteoarthritis-related arthroplasty, disc herniation, osteomyelitis, etc. Skin complications in orthopedic patients included hypersensitivity reactions in 35 (66.03%) cases, infections in 14 (26.4%) cases and 4 (7.5%) cases with other complications. Severe reactions presenting as toxic epidermal necrolysis were observed in 1 patient, who recovered eventually. Age and gender were not related to the type of skin complications (P>0.05). Conclusion: Skin complications in orthopedic patients were not uncommon. These complications can lead to increased morbidity and rarely mortality in orthopedic patients emphasizing the need for preventive strategies, multidisciplinary approaches and evidence based interventions.