Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
This study goal was to create and describe the characteristics of a curcumin-containing solid lipid nanoparticle (SLN) dispersion. Tripalmitin and lecithin were used as the lipid core of the SLN, which was subsequently synthesised utilising the ultrasonication process and the chitosan (cs) surface coating. The coated SLN (cs-SLN), which had a considerable increase, with a mean particle size of 116.8 ±2.88 nm and an entrapment efficiency of more than 99%. In relation to tripalmitin, the zeta potential increased proportionately and achieved a plateau at 5% CS coating. The Fourier Transform Infrared (FTIR) analysis of SLNs indicated that there was no alteration in the CUR spectrum, suggesting that the lipid and CS components were compatible with CUR. When the coating amount exceeded 2.5% of tripalmitin, the particle size and zeta potential (ZP) remained stable even at 40°C for a period of 90 days. All SLN emulsion exhibited a considerably faster release of CUR compared to pure CUR powder. The release rate at pH 7.0 increased proportionally to the coating amount. Interestingly, at pH 3.0, a CS coating of 5.0% or higher reduced the rate of release. However, the CUR from cs-SLN was notably lower than that from uncoated SLNs