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ISSN 2063-5346
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Solid Self Nanoemulsifying Drug Delivery System as carrier for the enhancement of bioavailability of Benidipine with Telmisartan.

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Sheetal S. Buddhadev1* , Kevinkumar C. Garala2 , Mukeshkumar Nariya3 , Mohamed Rahamathulla
» doi: 10.48047/ecb/2022.11.11.41

Abstract

Background: Benidipine (BD) and Telmisartan (TEL), co-administered antihypertensive medicines in the BCS class II group, are characterized by inadequate bioavailability due to restricted water solubility. Self-nano emulsifying drug delivery systems (SNEDDS) offer efficient solubilization for weakly water-soluble medicines due to their ternary ingredients' solubilization and nanonization activity, driven by surfactant and cosolvent. SNEDDS formulations comprise surfactants and cosolvents that facilitate nano droplet dispersion.

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