The study focused on the development of a solid dispersion system (SDs) consisting of atorvastatin (ATV); berberine (BER); polymers: eudragit®L-100 (EDL) and polyvinyl pyrrolidone K 30 (PVP-K 30) to enhance the solubility and dissolution of poorly water-soluble drug and inclusion of bioenhancer in combination. The SDs were formulated using the conventional melting technique. The ATV, BER, PMs, and SDs were studied for the initial level of interaction by Fourier transforms infrared spectroscopy (FTIR). Further, SDs with satisfactory in-vitro dissolution were subjected to solid-state characterization by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray crystallography (XRD). SDs-5 formula containing ATV: BER with EDL®L-100 (1:1:5), ATV: BER: PVP-K30 (1:1:5) showed the satisfactory formation of the tertiary mixture and better dissolution as compared to other ratios, physical mixing and pure form of drugs. The phase solubility studies revealed enhanced solubility with both polymers but more found with PVP K 30 as compared to EDL®L-100, although both are hydrophilic polymers, the ease of hydrogen bond formation of PVP K 30 builds more profound solubility. FTIR study showed the absence of interaction. DSC and XRD studies indicated decreased crystallinity in SDs. SEM of SDs further confirmed there were no observable drug particles on the surface. Based on the results, the in-vitro dissolution of the ATV was improved with ease in the incorporation of berberine through the SDs method. Hence, solid dispersion techniques can be effectively used for inclusion as well as for solubility enhancement.