The aim of present research work was to formulate and evaluate an immediate release tablet of Chlorzoxazone SD by direct compression, it is an API used in the treatment of muscle spasm. Chlorzoxazone is a BCS II drug with poor solubility and high permeability. Design-Expert® version13 software was used for designing 32 full factorial designs for selection of concentrations of Superdisintegrants i.e. SSG and CCS. Then formulated F9 batches were evaluated for Tablet Appearance, Weight Variation, Thickness, Hardness, Friability, Drug Content, Disintegration Test, Water Absorption Ratio, Uniformity of dispersion, In-vitro Dissolution Test and Stability Studies. Instrumental analysis viz. FTIR, DSC and XRD studies were carried out. F2 batch is an optimized batch, has shown most satisfactory results. Therefore, as per the findings, formulation met goals of increasing solubility, dissolution rate, % friability, hardness, water absorption ratio, convenience of administration, and safety.