The study's goal was to use the Liquisolid approach to increase Famotidine's solubility, an insoluble drug, to make it soluble, free-flowing, non-adherent powder mix that can be further used for various dosage forms. The investigation began with a pre formulation study in which the drug's appearance, melting point, solubility, and identity were determined using FTIR spectroscopy, DSC, and XRD.Calibration curve was obtained of Famotidine in Phosphate buffer pH 4.5 that indicated that good linearity as per Beer's law. Furthermore, the adsorbent load factor was calculated to estimate the approximate amount of non-volatile solvent that might be included in the Carrier-Coating System. Liqui- solid mixture was prepared by using Drug :Tween 80 1:1 &1:2. Microcrystalline Cellulose and Aerosil200 used as carrier and coating materialin 50% ratio provided greater release of drug (95.87 % in 30mins) among all trials,clearly revealing that the Liqui -solid technology has successfully improved Famotidine dissolution.This novel approach may be helpful to improve oral bioavailability