Background: Breast cancer is a malignant tumor primarily affecting women. Some women develop benign breast lumps, which are noncancerous abnormal growths not life-threatening. Aim: The aim of the study was to assess knowledge, attitude and practice towards breast cancer of undergraduate nurse students at nursing institutions Lahore. Methodology: A descriptive cross-sectional research study design was used. Study used purposive sampling. The study population was undergraduate nurse students and sample size was 133. Result: The study was descriptive cross-sectional so descriptive statistic was applied. Frequency distribution was calculated, data normality was checked. The study reported that the majority participants had low knowledge about breast cancer were 60(45.1%), those with moderate knowledge were 32(24.1%), and those with high knowledge were 41(30.8%). The positive attitude towards breast cancer was 72(54.1%), and those with negative attitude were 61(45.9%). The bad practice towards breast cancer was 74(55.6%), and those with good practice were 59(44.4%). Conclusion: The study concluded that the overall knowledge was poor and practices of breast cancer were bad but undergraduate students’ attitude towards breast cancer was positive.