A new analytical simple, accurate, precise, sensitive, rapid Ultra Performance Liquid chromatography (UPLC) method has been developed and validated for determination of Safinamide in bulk and its marketed pharmaceutical dosage form. Chromatographic separation was achieved on a Endeversil C18 ODS (2.1mm x 50mm, 3µm) column, by a mobile phase which consisted of 70% buffer (0.1% Octa sulphonic acid) and 30% Methanol taken in the ratio of 70:30% v/v, maintained pH to 3.0 with ortho phosphoric acid solution along with a flow rate of 0.2 ml/min