The present study deals with development and validation of a simple, precise, accurate, sensitive, specific and reliable stability indicating RP-HPLC method for simultaneous estimation of Nebivolol (NE Biv) and Valsartan (VAL) in pharmaceutical dosage form. This method was developed with mobile phase containing ACN, Potassium Dihydrogen orthophosphate and buffer (0.1% v/v ortho phosphoric acid (OPA) in water, pH = 3) in the ratio of (50:50), C18 (250 x 4.6mm, 5μm) as a stationary phase and flow rate (1 ml/min). Detection was carried out at 282 nm in UV-2000 detector. The selected chromatographic conditions were found effectively to separate Valsartan and Nebivolol at 4.27 and 6.96 min respectively. The proposed method has been validated for precision, accuracy, robustness. Thus, the statistical analysis confirms that developed methods were successfully used for analysis of formulation and routine analysis of drugs in Quality Control laboratories.