The level of stress burden and coping abilities among caregivers of children with Cerebral Palsy has been assessed among the 30 primary caregivers of children with cerebral palsy aged 4-12 years in Pediatric Rehabilitation Department, ‘King Abdullah Specialist Children’s Hospital (KASCH), National Guard Health Affairs (NGHA), Riyadh. Modified Short form Zarit burden interview Questionnaire (ZBI-12) to assess the level of caregiver’s stress burden and Brief Cope inventory modified to assess the coping strategies among the caregiver’s coping ability has been used. Results reveals that, the comparison of Overall Stress burden among Caregivers of children with Cerebral palsy for Study and Control group reveals that t = 3.142, p = 0.003 (Significant at P<0.01 level). The Level of Overall Stress burden among Caregivers of children with Cerebral palsy for Study and Control group chi square ‘p’ value was χ 2 = 12.381, d.f = 2, p=0.002 (Significant at P<0.01 Level). Hence, there was an association between Overall COPE and demographic variables among children with Cerebral palsy for Study group on the ‘Types of cerebral palsy’ and the ‘Employment status of caregiver’ whereas in the control group only ‘Other people involved in the child care’ was significant.