Stress is a major concern for researchers because of its negative impacts on human body and human mind. The effect of stress on people varies especially based on the demographic profiles. In this study, the stress levels of senior citizens who are staying in old age homes are considered. The main purpose of the study is to compare the stress levels of senior citizens based on their demographic characters. In this study, 220 senior citizens from the old age homes of Karnataka and Kerala; aged between 60-90 years are studied. Stratified random sampling method is used to select the sample for the study. Perceived Stress Scale (Sheldon Cohen, 1994) was modified standardised and used to measure the stress levels of the senior citizens. The result showed that there are significant differences on the stress level based on age, education, religion and profession. The difference is not significant on the basis of gender, marital status and the type of family.