The stress hormones cortisol and dehydroepiandrosterone were studied in 65 pregnant women admitted to the Karakalpak branch of the Republican Scientific Center for Emergency Medical Care over the past 3 years. The analysis of injuries showed that 20 women (30.7%) received an accident, 33 pregnant women (50.8%) – domestic injuries and 12 women (18.5%)- burns. According to the gestation period, 14 (21.5%) were injured in the first trimester, 29 (44.6%) in the second trimester and 22 (33.8%) pregnant women in the third trimester. There were 28 first-time pregnancies (43.1%), and 37 second-time pregnancies (56.9%). High cortisol levels were found in pregnant women with burns and accidents, which was 2.4 and 1.8 times higher compared to the normative data. According to the gestation period, the highest cortisol index was observed in pregnant women in the second trimester. Regardless of the gestation period in pregnant women with road accidents and burns, there was a significant 2-fold decrease in dehydroepiandrosterone compared with the normative data. In pregnant women with household injuries, the concentration of cortisol and dehydroepiandrosterone had no statistically significant differences from the normative data regardless of the gestation period.