The pure sulphamic acid (SA) and some amino acids added sulphamic acid crystals were grown successfully by slow evaporation technique at room temperature. The structural studies revealed that both SA and amino acids added SA crystals possessed orthorhombic crystal structure. The presence of vibrational modes and existence of carbon in the system was also confirmed using FTIR analysis. The surface morphology of crystals was studied. The optical transparency and band gap of the grown crystals were calculated. The hardness of amino acid added crystal is relatively higher than that of the pure SA crystals. The thermal stability of the grown crystals was analyzed by thermo gravimetric and differential thermal analysis (TGA/DTA), which revealed that the grown crystals were thermally stable and elevated from 261oC to 278oC for amino acid added crystals. The photoluminescence emission studies of grown crystals indicated the blue and green emission at 491 nm and 542nm, due to transition from the 5D4 excited state to 7F6 and 7F5 ground states respectively. The antibacterial activity studies showed that the grown crystals were more effective in killing pathogenic bacteria’s which affect the human beings